Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes

Abstract

Introduction We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D). Material and methods A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA 1c ), inflammation, OS and lipid parameters were measured. Associations of clinical data with HbA 1c level were tested with univariate and multivariate logistic ordinal regression analysis. HbA 1c as a dependent variable is given at the ordinal level (i.e. 6.4%, respectively). Results Endocan was significantly higher in the T2D group than in the controls. As endocan concentration rose by 1 unit, the probability for higher HbA 1c concentration increased by more than 3 times (OR = 3.69, 95% CI: 1.84–7.01, p < 0.001). Also, a rise in the dyslipidemia score, oxy score, inflammation score and DOI score by 1 unit increased the probability of higher HbA 1c concentration by 19%, 13%, 51% and 11%, respectively. In the models, after adjustment for confounding variables, endocan and DOI score remained independent predictors of HbA 1c level. Conclusions Endocan and DOI score are independently correlated with HbA 1c in patients with prediabetes and overt T2D.

Keywords

• inflammation
• diabetes
• oxidative stress
• glycemic control
• endocan