Use of autogenous platelet rich plasma and 3D collagen matrix Fibromatrix for soft tissue regeneration in the treatment of Miller Class I gingival recessions

Abstract

Background: Evaluation of the effectiveness of the integrated use of autogenous platelet plasma and 3D collagen matrix Fibromatrix for the regeneration of soft tissues of the oral cavity in the surgical treatment of Miller Class I gingival recession. Materials and Method: 25 patients were examined and treated. All patients underwent surgical treatment of gingival recession using two-layer techniques of eliminating gingival recession with «3D collagen matrix FibroMATRIX» for the regeneration of soft tissues of the oral cavity and autologous platelet plasma. In all cases, the rehydration of the collagen matrix was carried out in autogenous platelet plasma for 2 minutes. The result was evaluated after 7th day, 14th day, 1 and 3 months. Statistical processing of the studies was carried out in GraphPadPrism v.6.0, using the t-test, Mann-Whitney. Differences were considered significant at p <0.05. Results: Assessment of gingival recession closure and its significant (p <0.05) increase, corresponding to 85% efficiency after treatment in both groups of patients, no significant differences were found in both groups. The best clinical results were achieved in eliminating gingival recessions in the anterior maxilla, showing its 100% efficiency. Conclusions: The combined use of autogenous platelet plasma and 3D collagen matrix Fibromatrix for the regeneration of soft tissues of the oral cavity is an effective method for treating Miller Class I gingival recession.