Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

Peter J. Stogios; Emily Bordeleau; Zhiyu Xu; Tatiana Skarina; Elena Evdokimova; Sommer Chou; Luke Diorio-Toth; Alaric W. D’Souza; Sanket Patel; Gautam Dantas; Gerard D. Wright; Alexei Savchenko

doi:10.1038/s42003-022-03219-w

Communications Biology (Mar 2022)

Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

Peter J. Stogios,
Emily Bordeleau,
Zhiyu Xu,
Tatiana Skarina,
Elena Evdokimova,
Sommer Chou,
Luke Diorio-Toth,
Alaric W. D’Souza,
Sanket Patel,
Gautam Dantas,
Gerard D. Wright,
Alexei Savchenko

Affiliations

Peter J. Stogios: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Emily Bordeleau: David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University
Zhiyu Xu: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Tatiana Skarina: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Elena Evdokimova: Department of Chemical Engineering and Applied Chemistry, University of Toronto
Sommer Chou: David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University
Luke Diorio-Toth: The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine
Alaric W. D’Souza: The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine
Sanket Patel: The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine
Gautam Dantas: The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine
Gerard D. Wright: David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University
Alexei Savchenko: Department of Chemical Engineering and Applied Chemistry, University of Toronto

DOI: https://doi.org/10.1038/s42003-022-03219-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

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A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal