Targeting autophagy-related protein kinases for potential therapeutic purpose

Honggang Xiang; Jifa Zhang; Congcong Lin; Lan Zhang; Bo Liu; Liang Ouyang

Acta Pharmaceutica Sinica B (Apr 2020)

Targeting autophagy-related protein kinases for potential therapeutic purpose

Honggang Xiang,
Jifa Zhang,
Congcong Lin,
Lan Zhang,
Bo Liu,
Liang Ouyang

Affiliations

Honggang Xiang: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
Jifa Zhang: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
Congcong Lin: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
Lan Zhang: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; Corresponding authors. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Tel./fax: +86 28 85164063.
Bo Liu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China; Corresponding authors. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Tel./fax: +86 28 85164063.
Liang Ouyang: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China; Corresponding authors. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Tel./fax: +86 28 85164063.

Journal volume & issue: Vol. 10, no. 4
pp. 569 – 581

Abstract

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Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays a significant role in the quality control of macromolecules and organelles. Since protein kinases are integral to the autophagy process, it is critically important to understand the role of kinases in autophagic regulation. At present, intervention of autophagic processes by small-molecule modulators targeting specific kinases has becoming a reasonable and prevalent strategy for treating several varieties of human disease, especially cancer. In this review, we describe the role of some autophagy-related kinase targets and kinase-mediated phosphorylation mechanisms in autophagy regulation. We also summarize the small-molecule kinase inhibitors/activators of these targets, highlighting the opportunities of these new therapeutic agents. KEY WORDS: Autophagy, Protein kinases, Autophagy-related kinase, Phosphorylation, Small-molecule kinase inhibitors/activators, Human disease therapy

Published in Acta Pharmaceutica Sinica B

ISSN: 2211-3835 (Print); 2211-3843 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b

About the journal