eLife (May 2016)
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer
- Andrea Strakova,
- Máire Ní Leathlobhair,
- Guo-Dong Wang,
- Ting-Ting Yin,
- Ilona Airikkala-Otter,
- Janice L Allen,
- Karen M Allum,
- Leontine Bansse-Issa,
- Jocelyn L Bisson,
- Artemio Castillo Domracheva,
- Karina F de Castro,
- Anne M Corrigan,
- Hugh R Cran,
- Jane T Crawford,
- Stephen M Cutter,
- Laura Delgadillo Keenan,
- Edward M Donelan,
- Ibikunle A Faramade,
- Erika Flores Reynoso,
- Eleni Fotopoulou,
- Skye N Fruean,
- Fanny Gallardo-Arrieta,
- Olga Glebova,
- Rodrigo F Häfelin Manrique,
- Joaquim JGP Henriques,
- Natalia Ignatenko,
- Debbie Koenig,
- Marta Lanza-Perea,
- Remo Lobetti,
- Adriana M Lopez Quintana,
- Thibault Losfelt,
- Gabriele Marino,
- Inigo Martincorena,
- Simón Martínez Castañeda,
- Mayra F Martínez-López,
- Michael Meyer,
- Berna Nakanwagi,
- Andrigo B De Nardi,
- Winifred Neunzig,
- Sally J Nixon,
- Marsden M Onsare,
- Antonio Ortega-Pacheco,
- Maria C Peleteiro,
- Ruth J Pye,
- John F Reece,
- Jose Rojas Gutierrez,
- Haleema Sadia,
- Sheila K Schmeling,
- Olga Shamanova,
- Richard K Ssuna,
- Audrey E Steenland-Smit,
- Alla Svitich,
- Ismail Thoya Ngoka,
- Bogdan A Vițălaru,
- Anna P de Vos,
- Johan P de Vos,
- Oliver Walkinton,
- David C Wedge,
- Alvaro S Wehrle-Martinez,
- Mirjam G van der Wel,
- Sophie AE Widdowson,
- Elizabeth P Murchison
Affiliations
- Andrea Strakova
- Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
- Máire Ní Leathlobhair
- Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
- Guo-Dong Wang
- State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
- Ting-Ting Yin
- State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
- Ilona Airikkala-Otter
- International Training Center, Worldwide Veterinary Service, Aruvankadu, India
- Janice L Allen
- Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia
- Karen M Allum
- World Vets, Fargo, United States
- Leontine Bansse-Issa
- Stichting Dierenbescherming Suriname, Paramaribo, Suriname
- Jocelyn L Bisson
- Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
- Artemio Castillo Domracheva
- Corozal Veterinary Hospital, University of Panama, Panama City, Panama
- Karina F de Castro
- Department of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil
- Anne M Corrigan
- St. George's University, True Blue, Grenada
- Hugh R Cran
- The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya
- Jane T Crawford
- Animal Medical Centre, Belize City, Belize
- Stephen M Cutter
- Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia
- Laura Delgadillo Keenan
- Veterinary clinic Sr. Dog's, Guadalajara, Mexico
- Edward M Donelan
- Animal Management in Rural and Remote Indigenous Communities, Darwin, Australia
- Ibikunle A Faramade
- National Veterinary Research Institute, Vom, Nigeria
- Erika Flores Reynoso
- International Fund for Animal Welfare, Quintana Roo, Mexico
- Eleni Fotopoulou
- Intermunicipal Stray Animals Care Centre, Perama, Greece
- Skye N Fruean
- Animal Protection Society of Samoa, Apia, Samoa
- Fanny Gallardo-Arrieta
- Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela
- Olga Glebova
- Veterinary clinic BIOCONTROL, Moscow, Russia
- Rodrigo F Häfelin Manrique
- Veterinary clinic El Roble, Santiago de Chile, Chile
- Joaquim JGP Henriques
- OnevetGroup, Centro Veterinário Berna, Lisboa, Portugal
- Natalia Ignatenko
- Veterinary clinic Zoovetservis, Kiev, Ukraine
- Debbie Koenig
- World Vets, Fargo, United States
- Marta Lanza-Perea
- St. George's University, True Blue, Grenada
- Remo Lobetti
- Bryanston Veterinary Hospital, Bryanston, South Africa
- Adriana M Lopez Quintana
- Veterinary Clinic Lopez Quintana, Maldonado, Uruguay
- Thibault Losfelt
- Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, France
- Gabriele Marino
- Department of Veterinary Sciences, University of Messina, Messina, Italy
- Inigo Martincorena
- Wellcome Trust Sanger Institute, Hinxton, United Kingdom
- Simón Martínez Castañeda
- Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico
- Mayra F Martínez-López
- School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador
- Michael Meyer
- Touray & Meyer Vet Clinic, Serrekunda, Gambia
- Berna Nakanwagi
- The Kampala Veterinary Surgery, Kampala, Uganda
- Andrigo B De Nardi
- Department of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, Brazil
- Winifred Neunzig
- World Vets, Fargo, United States
- Sally J Nixon
- Vets Beyond Borders, The Rocks, Australia
- Marsden M Onsare
- Aniworld veterinary clinic, Kisumu, Kenya
- Antonio Ortega-Pacheco
- Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico
- Maria C Peleteiro
- Interdisciplinary Centre of Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal
- Ruth J Pye
- Vets Beyond Borders, The Rocks, Australia
- John F Reece
- Help in Suffering, Jaipur, India
- Jose Rojas Gutierrez
- Veterinary clinic Dr José Rojas, Los Andes, Chile
- Haleema Sadia
- University of Veterinary and Animal Sciences, Lahore, Pakistan
- Sheila K Schmeling
- Corozal Veterinary Clinic, Corozal Town, Belize
- Olga Shamanova
- Veterinary clinic Vetmaster, Ramenskoye, Russia
- Richard K Ssuna
- Lilongwe Society for Protection and Care of Animals, Lilongwe, Malawi
- Audrey E Steenland-Smit
- Stichting Dierenbescherming Suriname, Paramaribo, Suriname
- Alla Svitich
- State Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine
- Ismail Thoya Ngoka
- Kenya Society for Protection and Care of Animals, Nairobi, Kenya
- Bogdan A Vițălaru
- Clinical Sciences Department, Faculty of Veterinary Medicine, Bucharest, Romania
- Anna P de Vos
- Ladybrand Animal Clinic, Ladybrand, South Africa
- Johan P de Vos
- Veterinary Oncology Referral Centre De Ottenhorst, Terneuzen, Netherlands
- Oliver Walkinton
- Vets Beyond Borders, The Rocks, Australia
- David C Wedge
- Wellcome Trust Sanger Institute, Hinxton, United Kingdom
- Alvaro S Wehrle-Martinez
- Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay
- Mirjam G van der Wel
- Animal Anti Cruelty League, Port Elizabeth, South Africa
- Sophie AE Widdowson
- Lilongwe Society for Protection and Care of Animals, Lilongwe, Malawi
- Elizabeth P Murchison
- ORCiD
- Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
- DOI
- https://doi.org/10.7554/eLife.14552
- Journal volume & issue
-
Vol. 5
Abstract
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.
Keywords
