Frontiers in Neurology (Mar 2023)

Recent progress in patent foramen ovale and related neurological diseases: A narrative review

  • Fanfan Shi,
  • Leihao Sha,
  • Hua Li,
  • Yusha Tang,
  • Litao Huang,
  • Huizhen Liu,
  • Xu Li,
  • Lin Li,
  • Wenjie Yang,
  • Deying Kang,
  • Deying Kang,
  • Lei Chen

DOI
https://doi.org/10.3389/fneur.2023.1129062
Journal volume & issue
Vol. 14

Abstract

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Patent foramen ovale (PFO) is a common congenital cardiac abnormality when the opening of the interatrial septum is not closed in adulthood. This abnormality affects 25% of the general population. With the development of precision medicine, an increasing number of clinical studies have reported that PFO is closely related to various neurological diseases such as stroke, migraine, obstructive sleep apnea, and decompression syndrome. It has also been suggested that PFO closure could be effective for preventing and treating these neurological diseases. Therefore, increasing attention has been given to the prevention, diagnosis, and treatment of PFO-related neurological diseases. By reviewing existing literature, this article focuses on the pathogenesis, epidemiology, and clinical characteristics of PFO-related neurological diseases, as well as the prevention and treatment of different neurological diseases to discuss, and aims to provide current progress for this field and decision-making evidence for clinical practice.

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