Modification of Antibiotic Activity by Fixed Oil of the <i>Artocarpus heterophyllus</i> Almond against Standard and Multidrug-Resistant Bacteria Strains
Cícera Janayne Ferreira Dias,
António Raposo,
Cícera Dayane Thais de Sousa,
José Bezerra de Araújo-Neto,
Saulo Relison Tintino,
Cícera Datiane de Morais Oliveira-Tintino,
Isaac Moura Araújo,
Henrique Douglas Melo Coutinho,
Mayra Garcia Maia Costa,
Cleidiane Gomes Lima,
Mairlane Silva de Alencar,
Conrado Carrascosa,
Ariana Saraiva,
Erlânio Oliveira de Sousa
Affiliations
Cícera Janayne Ferreira Dias
Laboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, Brazil
António Raposo
CBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal
Cícera Dayane Thais de Sousa
Laboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, Brazil
José Bezerra de Araújo-Neto
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Crato 63105-000, Brazil
Saulo Relison Tintino
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Crato 63105-000, Brazil
Cícera Datiane de Morais Oliveira-Tintino
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Crato 63105-000, Brazil
Isaac Moura Araújo
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Crato 63105-000, Brazil
Henrique Douglas Melo Coutinho
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Program of Post-Graduation in Molecular Bioprospection, Regional University of Cariri, Crato 63105-000, Brazil
Mayra Garcia Maia Costa
Laboratory of Instrumental Chemistry, Nucleus of Technology and Industrial Quality of Ceará, Fortaleza 60440-552, Brazil
Cleidiane Gomes Lima
Laboratory of Instrumental Chemistry, Nucleus of Technology and Industrial Quality of Ceará, Fortaleza 60440-552, Brazil
Mairlane Silva de Alencar
Laboratory of Instrumental Chemistry, Nucleus of Technology and Industrial Quality of Ceará, Fortaleza 60440-552, Brazil
Conrado Carrascosa
Department of Animal Pathology and Production, Bromatology and Food Technology, Faculty of Veterinary, Universidad de Las Palmas de Gran Canaria, Trasmontaña s/n, 35413 Arucas, Spain
Ariana Saraiva
Department of Animal Pathology and Production, Bromatology and Food Technology, Faculty of Veterinary, Universidad de Las Palmas de Gran Canaria, Trasmontaña s/n, 35413 Arucas, Spain
Erlânio Oliveira de Sousa
Laboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri, Juazeiro do Norte 63041-190, Brazil
Artocarpus heterophyllus (jackfruit) is an evergreen tree distributed in tropical regions and is among the most studied species of the genus Artocarpus. The jackfruit almond has been highlighted in relation to phytochemical studies, biological properties, and application in the development of food products. This study aimed to analyze jackfruit fixed oil regarding chemical components, antibacterial property alone, and in association with antibiotics against standard and MDR bacteria strains. In the analysis of the oil by gas chromatography coupled to a flame ionization detector (GC-FID), a high content of saturated fatty acids (78.51%) was identified in relation to unsaturated fatty acids (17.07%). The main fatty acids identified were lauric acid (43.01%), myristic acid (11.10%), palmitic acid (6.95%), and oleic acid (15.32%). In the antibacterial analysis, broth microdilution assays were used. The oil presented minimum inhibitory concentration (MIC) ≥ 1024 μg/mL in antibacterial analysis for standard and MDR bacterial strains. The oil showed synergistic effects in the association with gentamicin, ofloxacin, and penicillin against MDR strains, with significant reductions in the MIC of antibiotics. The results suggest that the fixed oil of A. heterophyllus has fatty acids with the potential to synergistically modify antibiotic activity.
