Frontiers in Pharmacology (Jul 2023)
Overview of research progress and application of experimental models of colorectal cancer
- Li Liu,
- Li Liu,
- Li Liu,
- Qiuying Yan,
- Qiuying Yan,
- Zihan Chen,
- Xiaoman Wei,
- Lin Li,
- Dongxin Tang,
- Jiani Tan,
- Jiani Tan,
- Changliang Xu,
- Changliang Xu,
- Chengtao Yu,
- Chengtao Yu,
- Yueyang Lai,
- Yueyang Lai,
- Minmin Fan,
- Minmin Fan,
- Lihuiping Tao,
- Lihuiping Tao,
- Weixing Shen,
- Weixing Shen,
- Liu Li,
- Liu Li,
- Mianhua Wu,
- Haibo Cheng,
- Haibo Cheng,
- Dongdong Sun,
- Dongdong Sun,
- Dongdong Sun
Affiliations
- Li Liu
- School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Li Liu
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Li Liu
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Qiuying Yan
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Qiuying Yan
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Zihan Chen
- School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Xiaoman Wei
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Lin Li
- School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Dongxin Tang
- The First Clinical Medical College, Guizhou University of Traditional Chinese Medicine, Guiyang, China
- Jiani Tan
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Jiani Tan
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Changliang Xu
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Changliang Xu
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Chengtao Yu
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Chengtao Yu
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Yueyang Lai
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Yueyang Lai
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Minmin Fan
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Minmin Fan
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Lihuiping Tao
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Lihuiping Tao
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Weixing Shen
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Weixing Shen
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Liu Li
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Liu Li
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Mianhua Wu
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Haibo Cheng
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Haibo Cheng
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- Dongdong Sun
- School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Dongdong Sun
- Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Dongdong Sun
- Research Center for Pathogenesis Theory of Cancerous Toxin and Application, Nanjing University of Chinese Medicine, Nanjing, China
- DOI
- https://doi.org/10.3389/fphar.2023.1193213
- Journal volume & issue
-
Vol. 14
Abstract
Colorectal cancer (CRC) is the third most common malignancy in terms of global tumor incidence, and the rates of morbidity and mortality due to CRC are rising. Experimental models of CRC play a vital role in CRC research. Clinical studies aimed at investigating the evolution and mechanism underlying the formation of CRC are based on cellular and animal models with broad applications. The present review classifies the different experimental models used in CRC research, and describes the characteristics and limitations of these models by comparing the research models with the clinical symptoms. The review also discusses the future prospects of developing new experimental models of CRC.
Keywords
