Antibiotic Resistance Pattern of Bacterial Agents Isolated from Blood Culture of Patients with Infective Endocarditis

Abstract

Background and purpose: The prevalence of bacterial infections and the type of bacteria involved in causing endocarditis and knowing their antibiotic resistance pattern are very important for the correct selection of antibiotics to treat these infections and the proper control of infection in the hospital. In this retrospective cross-sectional descriptive study, we investigated the antibiotic resistance pattern of bacterial agents isolated from blood cultures of patients with infective endocarditis. Materials and methods: This retrospective study was conducted on patients with infective endocarditis admitted to Razi and Fatemeh Zahra teaching hospitals over the four years from 2019 to 2023. After collecting the data, it was entered into Excel software and then analyzed using SPSS version 19 software. Results: Among 28 patients included in the study, 57.1% were men and 42.9% were women; the median age of patients was 56.79±13.41 years. The most common isolated microorganism was Staphylococcus aureus with 11 positive samples (39.2%). Ninety-three percent of the studied microorganisms were resistant to at least two drugs. The result of the treatment was not significantly related to any of the gender, type of valve, and type of isolated microorganism (P=0.624, P=1.000 and P=0.398, respectively). Conclusion: In this study, gram-positive bacteria were the most common group of microorganisms causing infective endocarditis. A high percentage of resistance was observed against some antibiotics including penicillin, ceftazidime, and ceftriaxone, which should be considered in initial empiric antibiotic therapy among hospitalized patients with infective endocarditis

Keywords

• antibiotic
• antimicrobial resistance
• bacterial infections
• endocarditis