International Journal of Nanomedicine (Mar 2022)
Antimicrobial Coating: Tracheal Tube Application
Abstract
Xuemeng Chen,1 Xiaomei Ling,2 Gaowang Liu,1 Jinfang Xiao1 1Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Anesthesiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Jinfang Xiao, Department of Anaesthesiology, Nanfang Hospital, Southern Medical University, Jingxi Street, Guangzhou, 510515, Guangdong, People’s Republic of China, Tel +86 198 6518 2069, Email [email protected]: Ventilator-associated pneumonia (VAP) is a common and serious nosocomial infection in mechanically ventilated patients, increasing mortality, prolonging the patient length of stay, and increasing costs. In recent years, extensive studies on ventilator-associated pneumonia have shown that tracheal intubation plays an essential role in the pathogenesis of VAP, with the primary mechanism being the rapid colonization of the tracheal intubation surface by microbiota. Antibiotics do not combat microbial airway colonization, and antimicrobial coating materials offer new ideas to solve this problem. This paper reviews the current research progress on the role of endotracheal tube (ET) biofilms in the pathogenesis of VAP and antimicrobial coating materials.Keywords: antibacterial, biofilm, materials, ventilator-associated pneumonia
