Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Christopher R. Shaler; Alexandra A. Parco; Wael Elhenawy; Jasmeen Dourka; Jennifer Jury; Elena F. Verdu; Brian K. Coombes

doi:10.1038/s41467-021-26992-4

Nature Communications (Nov 2021)

Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts

Christopher R. Shaler,
Alexandra A. Parco,
Wael Elhenawy,
Jasmeen Dourka,
Jennifer Jury,
Elena F. Verdu,
Brian K. Coombes

Affiliations

Christopher R. Shaler: Department of Biochemistry and Biomedical Sciences, McMaster University
Alexandra A. Parco: Department of Biochemistry and Biomedical Sciences, McMaster University
Wael Elhenawy: Department of Biochemistry and Biomedical Sciences, McMaster University
Jasmeen Dourka: Department of Biochemistry and Biomedical Sciences, McMaster University
Jennifer Jury: Farncombe Family Digestive Health Research Institute
Elena F. Verdu: Farncombe Family Digestive Health Research Institute
Brian K. Coombes: Department of Biochemistry and Biomedical Sciences, McMaster University

DOI: https://doi.org/10.1038/s41467-021-26992-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Altered gut microbiome and exacerbation of symptoms at times of psychological stress are feature characteristics of Crohn’s disease. Here authors show in a mouse model that psychological stress impairs IL-22-dependent protective immunity of the ileal mucosa, which allows invasive bacteria to colonise the gut.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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