Effect of an educational intervention on the number potential drug-drug interactions

Aigul Z. Mussina; Gaziza A. Smagulova; Galina V. Veklenko; Bibigul B. Tleumagambetova; Nazgul A. Seitmaganbetova; Aigul A. Zhaubatyrova; Lazzat M. Zhamaliyeva

Saudi Pharmaceutical Journal (Jul 2019)

Effect of an educational intervention on the number potential drug-drug interactions

Aigul Z. Mussina,
Gaziza A. Smagulova,
Galina V. Veklenko,
Bibigul B. Tleumagambetova,
Nazgul A. Seitmaganbetova,
Aigul A. Zhaubatyrova,
Lazzat M. Zhamaliyeva

Affiliations

Aigul Z. Mussina: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Abulhair Khan Avenue, 21-1-30, Aktobe 030020, Kazakhstan; Corresponding author at: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Maresyev str., 68, 030019 Aktobe, Kazakhstan.
Gaziza A. Smagulova: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Alia Moldagulova Avenue, 47-84, Aktobe 030000, Kazakhstan
Galina V. Veklenko: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Eset Batyr Street, 109-1-8, Aktobe 030000, Kazakhstan
Bibigul B. Tleumagambetova: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Almaty District, Residential Massif Kargaly, 2 Mikroroyon, 16v – 230, Aktobe 030000, Kazakhstan
Nazgul A. Seitmaganbetova: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, 131g Bokenbay Batyr Street – 126, Aktobe 030000, Kazakhstan
Aigul A. Zhaubatyrova: Department of Propedeutics of Internal Diseases and Clinical Pharmacology, West Kazakhstan Marat Ospanov State Medical University, Novatorov lane 1, Aktobe 030012, Kazakhstan
Lazzat M. Zhamaliyeva: Center for Family Medicine and Primary Care Research, West Kazakhstan Marat Ospanov State Medical University, Alia Moldagulova Avenue, 11B – 120, Aktobe 030019, Kazakhstan

Journal volume & issue: Vol. 27, no. 5
pp. 717 – 723

Abstract

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Background: The objective of this study was to evaluate effect of an Educational intervention on the number Potential Drug-Drug Interactions in the Emergency Hospital. Methods: The prevalence and structure of Major Drug-Drug Interactions at Emergency care Hospitals of Aktobe, Uralsk, Atyrau cities (Kazakhstan) were studied (pharmacoepidemiological, cross-sectional study). Educational interventions were developed and implemented to improve pharmacotherapy in the Cardiology Department of the Aktobe Emergency Hospital, followed by an assessment of their effect. Results: The effect of educational interventions was revealed, which led to a significant decrease in the indicators of drug interactions of the Major Drug-Drug Interactions by 18.2% (OR: 0.45; 95% CI, 0.25-to-0.82) in the cardiological patients of the Emergency Care Hospital of Aktobe city compared to the Regional Cardiology Center of Uralsk. Conclusion: The implementation of educational pharmacotherapy programs decreased the number of clinically significant drug interactions in the Cardiology Department of Emergency Hospitals. Keywords: Pharmacotherapy, Drug-drug interaction, Education, Cardiology

Published in Saudi Pharmaceutical Journal

ISSN: 1319-0164 (Print)
Publisher: Elsevier
Country of publisher: Saudi Arabia
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/saudi-pharmaceutical-journal/

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