Incidence, Risk Factors and Impact on Clinical Outcomes of Bloodstream Infections in Patients Hospitalised with COVID-19: A Prospective Cohort Study
Andrea Cona,
Alessandro Tavelli,
Andrea Renzelli,
Benedetta Varisco,
Francesca Bai,
Daniele Tesoro,
Alessandro Za,
Caterina Biassoni,
Lodovica Battaglioli,
Marina Allegrini,
Ottavia Viganò,
Lidia Gazzola,
Teresa Bini,
Giulia Carla Marchetti,
Antonella d’Arminio Monforte
Affiliations
Andrea Cona
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Alessandro Tavelli
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Andrea Renzelli
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Benedetta Varisco
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Francesca Bai
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Daniele Tesoro
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Alessandro Za
Central Health Care Management, ASST Santi Paolo e Carlo, Via di Rudinì 8, 20142 Milan, Italy
Caterina Biassoni
Microbiology Unit, ASST Santi Paolo e Carlo, Via di Rudinì 8, 20142 Milan, Italy
Lodovica Battaglioli
Microbiology Unit, ASST Santi Paolo e Carlo, Via di Rudinì 8, 20142 Milan, Italy
Marina Allegrini
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Ottavia Viganò
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Lidia Gazzola
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Teresa Bini
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Giulia Carla Marchetti
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
Antonella d’Arminio Monforte
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, Italy
With the aim of describing the burden and epidemiology of community-acquired/healthcare-associated and hospital-acquired bloodstream infections (CA/HCA-BSIs and HA-BSIs) in patients hospitalised with COVID-19, and evaluating the risk factors for BSIs and their relative impact on mortality, an observational cohort study was performed on patients hospitalised with COVID-19 at San Paolo Hospital in Milan, Italy from 24 February to 30 November 2020. Among 1351 consecutive patients hospitalised with COVID-19, 18 (1.3%) had CA/HCA-BSI and 51 (3.8%) HA-BSI for a total of 82 episodes of BSI. The overall incidence of HA-BSI was 3.3/1000 patient-days (95% CI 2.4–4.2). Patients with HA-BSI had a longer hospital stay compared to CA/HCA-BSI and no-BSI groups (27 (IQR 21–35) vs. 12 (7–29) vs. 9 (5–17) median-days, p p = 0.421). BSI was not associated with an increased risk of mortality (CA/HCA-BSI vs. non-BSI aOR 1.27 95% CI 0.41–3.90, p = 0.681; HA-BSI vs. non-BSI aOR 1.29 95% CI 0.65–2.54, p = 0.463). Upon multivariate analysis, NIMV/CPAP (aOR 2.09, 95% CI 1.06–4.12, p = 0.034), IMV (aOR 5.13, 95% CI 2.08–12.65, p p = 0.032) were confirmed as independent factors associated with HA-BSI. Development of HA-BSI did not significantly affect mortality. Patients treated with corticosteroid therapy had double the risk of developing BSI.