Frontiers in Oncology (Sep 2022)
Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview
- Xiangwan Miao,
- Xiangwan Miao,
- Xiangwan Miao,
- Beilei Wang,
- Beilei Wang,
- Beilei Wang,
- Kaili Chen,
- Kaili Chen,
- Kaili Chen,
- Rui Ding,
- Rui Ding,
- Rui Ding,
- Jichang Wu,
- Jichang Wu,
- Jichang Wu,
- Yi Pan,
- Yi Pan,
- Yi Pan,
- Peilin Ji,
- Peilin Ji,
- Peilin Ji,
- Bin Ye,
- Bin Ye,
- Bin Ye,
- Mingliang Xiang,
- Mingliang Xiang,
- Mingliang Xiang
Affiliations
- Xiangwan Miao
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Xiangwan Miao
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Xiangwan Miao
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Beilei Wang
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Beilei Wang
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Beilei Wang
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Kaili Chen
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Kaili Chen
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Kaili Chen
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Rui Ding
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Rui Ding
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Rui Ding
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jichang Wu
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jichang Wu
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Jichang Wu
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yi Pan
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yi Pan
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Yi Pan
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Peilin Ji
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Peilin Ji
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Peilin Ji
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Bin Ye
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Bin Ye
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Bin Ye
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mingliang Xiang
- Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mingliang Xiang
- Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
- Mingliang Xiang
- Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- DOI
- https://doi.org/10.3389/fonc.2022.1008361
- Journal volume & issue
-
Vol. 12
Abstract
Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the “vital” cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.
Keywords
