Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil
Luiz Marivando Barros,
Antonia Eliene Duarte,
Maria Flaviana Bezerra Morais-Braga,
Emily Pansera Waczuk,
Celeste Vega,
Nadghia Figueiredo Leite,
Irwin Rose Alencar de Menezes,
Henrique Douglas Melo Coutinho,
João Batista Teixeira Rocha,
Jean Paul Kamdem
Affiliations
Luiz Marivando Barros
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
Antonia Eliene Duarte
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
Maria Flaviana Bezerra Morais-Braga
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
Emily Pansera Waczuk
Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil
Celeste Vega
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
Nadghia Figueiredo Leite
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
Irwin Rose Alencar de Menezes
Program of Post-Graduation in Molecular Bioprospection, Laboratory of Pharmacology and Molecular Chemistry, Chemistry Biology Department, Regional University of Cariri, Crato, CEP 63105-000, Brazil
Henrique Douglas Melo Coutinho
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
João Batista Teixeira Rocha
Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil
Jean Paul Kamdem
Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil
Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography–mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases.
