Research progress of fibroblast growth factor receptor in gastric cancer

Abstract

The incidence and mortality of gastric cancer are in the forefront of the tumor, and the prognosis is poor, especially in the middle and advanced stage. Even with comprehensive treatment, the 5- year survival is very low. The development of precision medicine has extended the survival of patients, and fibroblast growth factor receptor (FGFR) has gradually become a popular target for the treatment of gastric cancer. In this paper, the common FGFR alteration types in gastric cancer and the exploration of FGFR inhibitors in the field of gastric cancer were reviewed, and the challenges were analyzed.

Keywords

• fibroblast growth factor receptor
• gastric cancer
• fibroblast growth factor receptor inhibitor
• tyrosine kinase inhibitor
• ligand trap
• monoclonal antibody
• gene amplification
• genetic mutation
• gene rearrangement