Positive Outcomes of Supplementation with Lecithin-Based Delivery Formulation of <i>Curcuma longa</i> and <i>Boswellia serrata</i> in IBS Subjects with Small Bowel Dysbiosis

Abstract

Background: Small bowel dysbiosis (SBD) is a frequent finding in subjects with irritable bowel syndrome (IBS). The sunflower lecithin (phytosome) formulation of Curcuma longa and Boswellia serrata demonstrated beneficial effects on intestinal microbiota. This study aimed to evaluate the impact of a lecithin-based delivery formulation of Curcuma longa and Boswellia serrata extracts (CUBO) on SBD in IBS subjects. Subjects: Forty-nine adult subjects with IBS and SBD were randomly supplemented for 30 days with CUBO and a low-FODMAP diet (LFD) (intervention) or with LFD and placebo (control group). Results: The intervention group showed a significant reduction in urinary indican (p p p p p p p < 0.001). The efficacy was 20% greater in males than in females. Conclusions: In IBS subjects, the intervention with CUBO and LFD shows a significantly higher reduction in SBD, abdominal pain, and bloating compared to LFD and placebo. Additional research is needed to confirm these data.

Keywords

• bloating
• dysbiosis
• <i>Boswellia serrata</i>
• <i>Curcuma longa</i>
• irritable bowel syndrome
• microbiota