A zebrafish model of combined saposin deficiency identifies acid sphingomyelinase as a potential therapeutic target

• Tejia Zhang,
• Ivy Alonzo,
• Chris Stubben,
• Yijie Geng,
• Chelsea Herdman,
• Nancy Chandler,
• Kim P. Doane,
• Brock R. Pluimer,
• Sunia A. Trauger,
• Randall T. Peterson

Affiliations

Tejia Zhang

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA

Ivy Alonzo

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA

Chris Stubben

Bioinformatic Analysis Shared Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA

Yijie Geng

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA

Chelsea Herdman

Department of Neurobiology and Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT 84112, USA

Nancy Chandler

Electron Microscopy Core Laboratory, University of Utah, Salt Lake City, UT 84112, USA

Kim P. Doane

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA

Brock R. Pluimer

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA

Sunia A. Trauger

Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA 02138, USA

Randall T. Peterson

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA