Data in Brief (Oct 2018)

Dataset on the response of Hut78 cells to novel rexinoids

  • Jennifer Hackney Price,
  • Bentley J. Hanish,
  • Carl E. Wagner,
  • Ichiro Kaneko,
  • Peter W. Jurutka,
  • Pamela A. Marshall

Journal volume & issue
Vol. 20
pp. 1797 – 1803

Abstract

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This article presents the experimental data supporting analysis of differential gene expression of human cutaneous T cell lymphoma (CTCL) cell culture cells (Hut78) treated with bexarotene or a variety of rexinoids, in conjunction with “A Novel Gene Expression Analytics-based Approach to Structure Aided Design of Rexinoids for Development as Next-Generation Cancer Therapeutics” (Hanish et al. 2018). Data presented here include microarray gene expression analysis of a subset of genes. A novel method for analyzing gene expression in the context of a model of ligand mechanism, called the Divergence Score, is described. Analysis to identify the presence of potential retinoid response elements in putative promoter regions of the study genes is also presented.