Chiral Supramolecular Hydrogel Loaded with Dimethyloxalyglycine to Accelerate Chronic Diabetic Wound Healing by Promoting Cell Proliferation and Angiogenesis
Yubo Zhang,
Weijie Cai,
Zun Ren,
Yuxiang Lu,
Musha Hamushan,
Pengfei Cheng,
Zhengyu Xu,
Hao Shen,
Changli Zhao,
Pei Han,
Wanrun Zhong
Affiliations
Yubo Zhang
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Weijie Cai
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Zun Ren
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Yuxiang Lu
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Musha Hamushan
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Pengfei Cheng
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Zhengyu Xu
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Hao Shen
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Changli Zhao
School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Pei Han
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Wanrun Zhong
Orthopedic Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Chronic refractory wounds are one of the most serious complications of diabetes, and the effects of common treatments are limited. Chiral hydrogel combined with dimethyloxalyglycine (DMOG) as a dressing is a promising strategy for the treatment of chronic wounds. In this research, we have developed a DMOG-loaded supramolecular chiral amino-acid-derivative hydrogel for wound dressings for full-thickness skin regeneration of chronic wounds. The properties of the materials, the ability of sustained release drugs, and the ability to promote angiogenesis were tested in vitro, and the regeneration rate and repair ability of full-thickness skin were tested in vivo. The chiral hydrogel had the ability to release drugs slowly. It can effectively promote cell migration and angiogenesis in vitro, and promote full-thickness skin regeneration and angiogenesis in vivo. This work offers a new approach for repairing chronic wounds completely through a supramolecular chiral hydrogel loaded with DMOG.
