Nature Communications (Sep 2019)
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
- Xueping Liu,
- Dorte Helenius,
- Line Skotte,
- Robin N. Beaumont,
- Matthias Wielscher,
- Frank Geller,
- Julius Juodakis,
- Anubha Mahajan,
- Jonathan P. Bradfield,
- Frederick T. J. Lin,
- Suzanne Vogelezang,
- Mariona Bustamante,
- Tarunveer S. Ahluwalia,
- Niina Pitkänen,
- Carol A. Wang,
- Jonas Bacelis,
- Maria C. Borges,
- Ge Zhang,
- Bruce A. Bedell,
- Robert M. Rossi,
- Kristin Skogstrand,
- Shouneng Peng,
- Wesley K. Thompson,
- Vivek Appadurai,
- Debbie A. Lawlor,
- Ilkka Kalliala,
- Christine Power,
- Mark I. McCarthy,
- Heather A. Boyd,
- Mary L. Marazita,
- Hakon Hakonarson,
- M. Geoffrey Hayes,
- Denise M. Scholtens,
- Fernando Rivadeneira,
- Vincent W. V. Jaddoe,
- Rebecca K. Vinding,
- Hans Bisgaard,
- Bridget A. Knight,
- Katja Pahkala,
- Olli Raitakari,
- Øyvind Helgeland,
- Stefan Johansson,
- Pål R. Njølstad,
- João Fadista,
- Andrew J. Schork,
- Ron Nudel,
- Daniel E. Miller,
- Xiaoting Chen,
- Matthew T. Weirauch,
- Preben Bo Mortensen,
- Anders D. Børglum,
- Merete Nordentoft,
- Ole Mors,
- Ke Hao,
- Kelli K. Ryckman,
- David M. Hougaard,
- Leah C. Kottyan,
- Craig E. Pennell,
- Leo-Pekka Lyytikainen,
- Klaus Bønnelykke,
- Martine Vrijheid,
- Janine F. Felix,
- William L. Lowe,
- Struan F. A. Grant,
- Elina Hyppönen,
- Bo Jacobsson,
- Marjo-Riitta Jarvelin,
- Louis J. Muglia,
- Jeffrey C. Murray,
- Rachel M. Freathy,
- Thomas M. Werge,
- Mads Melbye,
- Alfonso Buil,
- Bjarke Feenstra
Affiliations
- Xueping Liu
- Department of Epidemiology Research, Statens Serum Institut
- Dorte Helenius
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Line Skotte
- Department of Epidemiology Research, Statens Serum Institut
- Robin N. Beaumont
- Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
- Matthias Wielscher
- Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
- Frank Geller
- Department of Epidemiology Research, Statens Serum Institut
- Julius Juodakis
- Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg
- Anubha Mahajan
- Wellcome Centre for Human Genetics, University of Oxford
- Jonathan P. Bradfield
- Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Frederick T. J. Lin
- Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine
- Suzanne Vogelezang
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Mariona Bustamante
- ISGlobal, Barcelona Institute for Global Health
- Tarunveer S. Ahluwalia
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Niina Pitkänen
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Carol A. Wang
- School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
- Jonas Bacelis
- Department of Obstetrics and Gynecology, Sahlgrenska University Hospital
- Maria C. Borges
- MRC Integrative Epidemiology Unit at the University of Bristol
- Ge Zhang
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center
- Bruce A. Bedell
- Department of Pediatrics, University of Iowa
- Robert M. Rossi
- March of Dimes Prematurity Research Center Ohio Collaborative
- Kristin Skogstrand
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Shouneng Peng
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Wesley K. Thompson
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Vivek Appadurai
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Debbie A. Lawlor
- MRC Integrative Epidemiology Unit at the University of Bristol
- Ilkka Kalliala
- Department of Surgery and Cancer, IRDB, Faculty of Medicine, Imperial College
- Christine Power
- Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London
- Mark I. McCarthy
- Wellcome Centre for Human Genetics, University of Oxford
- Heather A. Boyd
- Department of Epidemiology Research, Statens Serum Institut
- Mary L. Marazita
- Center for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine, University of Pittsburgh
- Hakon Hakonarson
- Center for Applied Genomics, The Children’s Hospital of Philadelphia
- M. Geoffrey Hayes
- Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine
- Denise M. Scholtens
- Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Fernando Rivadeneira
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Vincent W. V. Jaddoe
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- Rebecca K. Vinding
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Hans Bisgaard
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Bridget A. Knight
- NIHR Exeter Clinical Research Facility, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
- Katja Pahkala
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Olli Raitakari
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Øyvind Helgeland
- K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Stefan Johansson
- K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen
- Pål R. Njølstad
- K. G. Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen
- João Fadista
- Department of Epidemiology Research, Statens Serum Institut
- Andrew J. Schork
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Ron Nudel
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Daniel E. Miller
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Xiaoting Chen
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Matthew T. Weirauch
- Department of Pediatrics, University of Cincinnati College of Medicine
- Preben Bo Mortensen
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Anders D. Børglum
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Merete Nordentoft
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Ole Mors
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Ke Hao
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Kelli K. Ryckman
- Department of Pediatrics, University of Iowa
- David M. Hougaard
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Leah C. Kottyan
- Department of Pediatrics, University of Cincinnati College of Medicine
- Craig E. Pennell
- School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle
- Leo-Pekka Lyytikainen
- Department of Clinical Chemistry, Fimlab Laboratories
- Klaus Bønnelykke
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
- Martine Vrijheid
- ISGlobal, Barcelona Institute for Global Health
- Janine F. Felix
- The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
- William L. Lowe
- Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine
- Struan F. A. Grant
- Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Elina Hyppönen
- Population, Policy and Practice, Great Ormond Street Institute for Child Health, University College London
- Bo Jacobsson
- Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg
- Marjo-Riitta Jarvelin
- Institute of Health Sciences, University of Oulu
- Louis J. Muglia
- Division of Human Genetics, Cincinnati Children’s Hospital Medical Center
- Jeffrey C. Murray
- Department of Pediatrics, University of Iowa
- Rachel M. Freathy
- Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
- Thomas M. Werge
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Mads Melbye
- Department of Epidemiology Research, Statens Serum Institut
- Alfonso Buil
- iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research
- Bjarke Feenstra
- Department of Epidemiology Research, Statens Serum Institut
- DOI
- https://doi.org/10.1038/s41467-019-11881-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Gestational duration depends on both maternal and fetal genetic influences. Here, the authors perform a fetal genome-wide association meta-analysis and find that a locus on 2q13 is associated with pregnancy duration and further show that the lead SNP rs7594852 changes the binding properties of transcriptional repressor HIC1.
