ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Ramesh B. Kasetti; Pinkal D. Patel; Prabhavathi Maddineni; Shruti Patil; Charles Kiehlbauch; J. Cameron Millar; Charles C. Searby; VijayKrishna Raghunathan; Val C. Sheffield; Gulab S. Zode

doi:10.1038/s41467-020-19352-1

Nature Communications (Nov 2020)

ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Ramesh B. Kasetti,
Pinkal D. Patel,
Prabhavathi Maddineni,
Shruti Patil,
Charles Kiehlbauch,
J. Cameron Millar,
Charles C. Searby,
VijayKrishna Raghunathan,
Val C. Sheffield,
Gulab S. Zode

Affiliations

Ramesh B. Kasetti: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth
Pinkal D. Patel: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth
Prabhavathi Maddineni: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth
Shruti Patil: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth
Charles Kiehlbauch: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth
J. Cameron Millar: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth
Charles C. Searby: Department of Pediatrics, Carver College of Medicine, University of Iowa
VijayKrishna Raghunathan: Department of Basic Sciences and the Ocular Surface Institute, College of Optometry, University of Houston
Val C. Sheffield: Department of Pediatrics, Carver College of Medicine, University of Iowa
Gulab S. Zode: Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth

DOI: https://doi.org/10.1038/s41467-020-19352-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma, thus suggesting a possible treatment strategy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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