Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

Rong Zhang; Ning Dong; Zhangqi Shen; Yu Zeng; Jiauyue Lu; Congcong Liu; Hongwei Zhou; Yanyan Hu; Qiaoling Sun; Qipeng Cheng; Lingbing Shu; Jiachang Cai; Edward Wai-Chi Chan; Gongxiang Chen; Sheng Chen

doi:10.1038/s41467-020-18475-9

Nature Communications (Sep 2020)

Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

Rong Zhang,
Ning Dong,
Zhangqi Shen,
Yu Zeng,
Jiauyue Lu,
Congcong Liu,
Hongwei Zhou,
Yanyan Hu,
Qiaoling Sun,
Qipeng Cheng,
Lingbing Shu,
Jiachang Cai,
Edward Wai-Chi Chan,
Gongxiang Chen,
Sheng Chen

Affiliations

Rong Zhang: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Ning Dong: Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Zhangqi Shen: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University
Yu Zeng: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Jiauyue Lu: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Congcong Liu: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Hongwei Zhou: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Yanyan Hu: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Qiaoling Sun: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Qipeng Cheng: Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Lingbing Shu: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Jiachang Cai: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Edward Wai-Chi Chan: State Key Lab of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University
Gongxiang Chen: Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine
Sheng Chen: Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong

DOI: https://doi.org/10.1038/s41467-020-18475-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Emergence of tigecycline-resistance tet(X) genes is of concern. Here, the authors determine tet(X) prevalence in more than 6,000 clinical Gram-negative bacterial isolates collected between 1994 to 2019 in hospitals in China and suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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