Nature Communications (Sep 2021)

TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

  • Zhongyu Xie,
  • Wenhui Yu,
  • Guan Zheng,
  • Jinteng Li,
  • Shuizhong Cen,
  • Guiwen Ye,
  • Zhaofeng Li,
  • Wenjie Liu,
  • Ming Li,
  • Jiajie Lin,
  • Zepeng Su,
  • Yunshu Che,
  • Feng Ye,
  • Peng Wang,
  • Yanfeng Wu,
  • Huiyong Shen

DOI
https://doi.org/10.1038/s41467-021-25710-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.