Nature Communications (May 2017)

ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo

  • Lena Kristina Beilschmidt,
  • Sandrine Ollagnier de Choudens,
  • Marjorie Fournier,
  • Ioannis Sanakis,
  • Marc-André Hograindleur,
  • Martin Clémancey,
  • Geneviève Blondin,
  • Stéphane Schmucker,
  • Aurélie Eisenmann,
  • Amélie Weiss,
  • Pascale Koebel,
  • Nadia Messaddeq,
  • Hélène Puccio,
  • Alain Martelli

DOI
https://doi.org/10.1038/ncomms15124
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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The mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.