Isolation and Bioassay of a New Terminalone A from <i>Terminalia arjuna</i>
Bushra,
Khalil ur Rehman,
Dilfaraz Khan,
Abdulrahman A. Almehizia,
Ahmed M. Naglah,
Asma S. Al-Wasidi,
Moamen S. Refat,
Mohamed Y. El-Sayed,
Hamid Ullah,
Shafiullah Khan
Affiliations
Bushra
Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
Khalil ur Rehman
Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
Dilfaraz Khan
Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
Abdulrahman A. Almehizia
Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Ahmed M. Naglah
Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Asma S. Al-Wasidi
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
Moamen S. Refat
Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Mohamed Y. El-Sayed
Chemistry Department, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia
Hamid Ullah
Department of Chemistry, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta 87300, Pakistan
Shafiullah Khan
Institute of Chemical Sciences, Gomal University, Dera Ismail Khan 29050, KPK, Pakistan
Terminalia arjuna possesses significant cardioprotective, antidiabetic and antioxidant properties as these properties are described in Ayurveda. In the present study, three flavonoids were isolated through the separation and chromatographic purification of the whole plant material of T. arjuna. Spectroscopic characterization identified one of them as a new flavonoid “Terminalone A (1)” and two known flavonoids i.e., 6-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one (2) and 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (3). The bioactivity studies showed considerable antibacterial and antioxidant (DPPH radical scavenging) potential for all the three compounds 1–3 where the compound 1 showed strong antibacterial and antioxidant activity.
