Nature Communications (Mar 2019)

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density

  • Alessandra Chesi,
  • Yadav Wagley,
  • Matthew E. Johnson,
  • Elisabetta Manduchi,
  • Chun Su,
  • Sumei Lu,
  • Michelle E. Leonard,
  • Kenyaita M. Hodge,
  • James A. Pippin,
  • Kurt D. Hankenson,
  • Andrew D. Wells,
  • Struan F. A. Grant

DOI
https://doi.org/10.1038/s41467-019-09302-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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GWAS have identified numerous genetic loci for bone mineral density (BMD) and fracture risk. Here, the authors map these variants to putative target genes using ATAC-seq and Capture C of human osteoblasts and confirm ING3 and EPDR1 as BMD genes in in vitro osteoblast differentiation experiments.