Multifunctional scaffolds of β-tricalcium phosphate/bioactive glass coated with zinc oxide and copper oxide nanoparticles
Rodrigo L.M.S. Oliveira,
Lucas Barbosa,
Thaís C. Pereira,
Luísa R.M. Dona,
Thiago G. Tabuti,
Dayane B. Tada,
Eduardo R. Triboni,
Luciane D. de Oliveira,
Eliandra S. Trichês
Affiliations
Rodrigo L.M.S. Oliveira
Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil
Lucas Barbosa
Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil
Thaís C. Pereira
Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP, 12245-000, São José dos Campos, SP, Brazil
Luísa R.M. Dona
Laboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil
Thiago G. Tabuti
Laboratory of Photochemistry and Functional Materials (FMF), Escola de Engenharia de Lorena, Universidade de São Paulo – EEL-USP, 12602-810, Lorena, SP, Brazil
Dayane B. Tada
Laboratory of Nanomaterials and Nanotoxicology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil
Eduardo R. Triboni
Laboratory of Photochemistry and Functional Materials (FMF), Escola de Engenharia de Lorena, Universidade de São Paulo – EEL-USP, 12602-810, Lorena, SP, Brazil
Luciane D. de Oliveira
Instituto de Ciência e Tecnologia, Universidade Estadual Paulista - UNESP, 12245-000, São José dos Campos, SP, Brazil
Eliandra S. Trichês
Bioceramics Laboratory, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo - UNIFESP, 12231-280, São José dos Campos, SP, Brazil; Corresponding author at: Eliandra de Sousa Trichês, 330 Talim Street, Vila Nair, Zip Code: 12231-280, São José dos Campos, SP, Brazil.
Incorporating nanoparticles into scaffolds with regenerative potential is a promissory strategy to provide them with antimicrobial activity. Bioceramics, such as β-tricalcium phosphate (β-TCP) and bioactive glasses (BGs), stand out among synthetic materials for bone regeneration. In this context, we report the incorporation of zinc oxide (ZnO) and copper oxide/copper nitrate (CuO/Cu2H3NO5) nanoparticles onto the surface of the β-TCP/BG scaffolds. This report addresses the physicochemical characterization of the scaffolds, their antimicrobial activity, and their response to MC3T3-E1 cells. Our findings show that the incorporation of both nanoparticles effectively inhibited S. aureus growth, including its biofilm formation. While the presence of the nanoparticles initially decreased MC3T3-E1 cell viability, cell proliferation improved with prolonged incubation. Overall, the β-TCP/BG_Zn and β-TCP/BG_Cu scaffolds showed an early antimicrobial response, aiding infection eradication, while also supporting cell proliferation over time.
