Antibacterial Activities of <i>Agaricus bisporus</i> Extracts and Their Synergistic Effects with the Antistaphylococcal Drug AFN-1252
Milica Jankov,
Vincent Léguillier,
Uroš Gašić,
Jamila Anba-Mondoloni,
Maja Krstić Ristivojević,
Aleksandra Radoičić,
Ivica Dimkić,
Petar Ristivojević,
Jasmina Vidic
Affiliations
Milica Jankov
Innovative Centre of the Faculty of Chemistry Ltd., Studentski trg 12-16, 11158 Belgrade, Serbia
Vincent Léguillier
Micalis, AgroParisTech, National Research Institute for Agriculture, Food and the Environment (INRAE), University Paris-Saclay, UMR 1319, 78350 Jouy en Josas, France
Uroš Gašić
Department of Plant Physiology, Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11108 Belgrade, Serbia
Jamila Anba-Mondoloni
Micalis, AgroParisTech, National Research Institute for Agriculture, Food and the Environment (INRAE), University Paris-Saclay, UMR 1319, 78350 Jouy en Josas, France
Maja Krstić Ristivojević
Department of Biochemistry, Centre of Excellence for Molecular Food Sciences, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia
Aleksandra Radoičić
Innovative Centre of the Faculty of Chemistry Ltd., Studentski trg 12-16, 11158 Belgrade, Serbia
Ivica Dimkić
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Belgrade, Studentski trg 16, 11158 Belgrade, Serbia
Petar Ristivojević
Department of Analytical Chemistry, Centre of Excellence for Molecular Food Sciences, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia
Jasmina Vidic
Micalis, AgroParisTech, National Research Institute for Agriculture, Food and the Environment (INRAE), University Paris-Saclay, UMR 1319, 78350 Jouy en Josas, France
Agaricus bisporus, commonly known as the button mushroom, has attracted attention for its biological properties, including antimicrobial activities. Here, we evaluated the efficacy of ethanolic and acetonic extracts from white and brown A. bisporus against different bacterial strains, including antibiotic-resistant strains. Bioautography and principal component analysis identified the most active antibacterial compounds for each of the tested bacteria and indicated the main markers responsible for the strain-specific effects. In addition, the mushroom extracts demonstrated a synergistic impact when combined with the antistaphylococcal antibiotic AFN-1252.
