Nature Communications (Nov 2018)

Genetic dissection of the miR-200–Zeb1 axis reveals its importance in tumor differentiation and invasion

  • Alexandra C. Title,
  • Sue-Jean Hong,
  • Nuno D. Pires,
  • Lynn Hasenöhrl,
  • Svenja Godbersen,
  • Nadine Stokar-Regenscheit,
  • David P. Bartel,
  • Markus Stoffel

DOI
https://doi.org/10.1038/s41467-018-07130-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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In vivo studies on the regulation of the epithelial-mesenchymal transition (EMT) within a physiological context are lacking. Here it is shown that miR-200 ablation in the Rip-Tag2 insulinoma mouse model induces beta-cell dedifferentiation, EMT and tumor invasion, and that disruption of Zeb1 regulation by miR-200c is sufficient to drive EMT.