Acta Cirúrgica Brasileira (Dec 2018)

Influence of tramadol on functional recovery of acute spinal cord injury in rats

  • Rosa Helena de Figueiredo Chaves,
  • Celice Cordeiro de Souza,
  • Ismari Perini Furlaneto,
  • Renan Kleber Costa Teixeira,
  • Carolina Pinheiro de Oliveira,
  • Emanuelle de Matos Rodrigues,
  • Daniel Arthur Santos dos Santos,
  • Renata Cunha Silva,
  • Nelson Elias Abrahão da Penha,
  • Ana Rita de Lima

DOI
https://doi.org/10.1590/s0102-865020180120000006
Journal volume & issue
Vol. 33, no. 12
pp. 1087 – 1094

Abstract

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Abstract Purpose: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. Methods: Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn’t receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods. Results: There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group. Conclusion: The tramadol as an analgesic agent don’t influence on functional recovery of acute spinal cord injury in rats

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