3D laser-printed porous Ti6Al4V dental implants for compromised bone support

Che Chang Tu; Pei-I Tsai; San-Yuan Chen; Mark Yen-Ping Kuo; Jui-Sheng Sun; Jenny Zwei-Chieng Chang

Journal of the Formosan Medical Association (Jan 2020)

3D laser-printed porous Ti6Al4V dental implants for compromised bone support

Che Chang Tu,
Pei-I Tsai,
San-Yuan Chen,
Mark Yen-Ping Kuo,
Jui-Sheng Sun,
Jenny Zwei-Chieng Chang

Affiliations

Che Chang Tu: Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Pei-I Tsai: Department of Materials Science and Engineering, National Chiao-Tung University, Hsinchu, Taiwan; Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu, Taiwan
San-Yuan Chen: Department of Materials Science and Engineering, National Chiao-Tung University, Hsinchu, Taiwan
Mark Yen-Ping Kuo: Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Jui-Sheng Sun: Department of Orthopedic Surgery, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei, Taiwan
Jenny Zwei-Chieng Chang: Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. School of Dentistry, College of Medicine, National Taiwan University, No 1 Chang-De Street, Taipei 10048, Taiwan. Fax: +886 2 23831346.

Journal volume & issue: Vol. 119, no. 1
pp. 420 – 429

Abstract

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Background/Purpose: Alveolar bone loss following peri-implantitis remains a clinical challenge. We aimed to design a novel bioactive dental implant to accommodate the large bone defect caused by removal of previously failed implant. Methods: Bio-ActiveITRI dental implant was manufactured with laser-sintered additive 3D printing technique. A 7.5 mm diameter × 7.0 mm depth osteotomy defect was created at the lateral aspect of distal femur of 20 New Zealand white rabbits to simulate the bony defect after removal of failed dental implant. One side of distal femurs was randomly selected for the commercially pure titanium NobelActive™ implant (control group) and the other side with Bio-ActiveITRI Ti6Al4V porous dental implant (ITRI group). Animals were sacrificed at 4, 8 and 12 weeks after the implants' insertion. The samples were processed for gross morphological analysis, radiographic examination, micro-CT evaluation, and mechanical testing. Results: In histomorphometrical evaluation and micro-CT analysis, active new bone formation and good osseointegration within the ITRI implants were observed at the bone gap surrounding the dental implants. The biomechanical parameters in the Bio-ActiveITRI dental implants were significantly higher than those of the commercially control samples. For the Bio-ActiveITRI dental implants, the trabecular thickness decreased, while the trabecular separation and total porosity increased from the prescribed 1-month to 3-month time points; reflecting the natural remodeling of surrounding bony tissue in the Bio-ActiveITRI dental implants. Conclusion: The novel porous structured Bio-ActiveITRI dental implants may have a great potential for the prosthetic reconstruction where bone support is compromised after removal of a previously failed implant. Keywords: Bio-ActiveITRI dental implant, Bone defect, Laser-sintered additive 3D printing

Published in Journal of the Formosan Medical Association

ISSN: 0929-6646 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: http://www.journals.elsevier.com/journal-of-the-formosan-medical-association/

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