Endothelial dysfunction and apoptosis in the pathogenesis of cognitive impairment in patients with arterial hypertension

Abstract

Eighty patients with arterial hypertension (AH), aged 52,4 years, were studied. A diagnosis of mild cognitive impairment (MCI) in 61 patients met traditional clinical approach, neuropsychological examination. Significant correlation between the level of cognitive dysfunction and blood concentration of NO, endothelin-1 and apoptosis markers in researching groups were found. The results obtained suggest that markers of endothelial dysfunction and apoptosis could prove to be the early predictors of cognitive impairment in patients with arterial hypertension.

Keywords

• артериальная гипертензия
• когнитивные нарушения
• эндотелиальная дисфункция
• апоптоз