Assessment of hemodynamic and vascular parameters in Alzheimer's disease, vascular dementia and mild cognitive abnormalities: a pilot study

Abstract

Abstract Objectives: this pilot study correlated cardiovascular parameters such as atherosclerosis and arterial stiffness in patients with aged-related dementia and sought to identify hemodynamic differences that can help in differential diagnosis. Method: a longitudinal prospective study was performed of 46 patients aged 60 to 80 years in the city of Belo Horizonte, Minas Gerais, Brazil. The patients were classified into three groups: those with Alzheimer’s disease (AD), vascular dementia (VD) or mild cognitive impairment (MCI). The groups were classified by clinical examination and CT or magnetic resonance imaging tests of the encephalon. The arterial stiffness and other hemodynamic parameters of the patients were measured using the Mobil-O-Graph device and carotid artery ultrasound scanning. Data analysis was performed by descriptive statistics, multinomial logistic regression and analysis of variance. Results: 18 patients (39.1%) had MCI, 18 (39.1%) AD and 10 (21.8%) VD. Image exams revealed greater obstructive microangiopathy in the AD group than the MCI group (p<0.05), which in turn exhibited greater normality in such tests than the AD group (p<0.05). There were no significant differences among the groups for the hemodynamic variables. The carotid artery ultrasound examinations identified a greater degree of normality in the MCI group than the AD group (p<0.05). Conclusion: the results do not support the idea of using noninvasive hemodynamic evaluation methods as additional exams in the differential diagnosis of these pathologies.

Keywords

• Dementia, Vascular
• Alzheimer Disease
• Pulse Wave Analysis
• Vascular Stiffness