Diagnostic Value of Adropin Levels in Acute Pulmonary Embolism Patients

Abstract

Aim:This study aimed to evaluate the relationship between serum adropin levels in patients with acute pulmonary embolism (PE).Materials and Methods:Patients pre-diagnosed with PE based on computed tomographic pulmonary angiography findings and not fulfilling any of the exclusion criteria were included in the PE group. An identical number of participants with comorbidities similar to those of the PE group were included in the control group. These patientswere selected from those who had been referred to the emergency department and were not considered to have PE based on clinical symptoms and risk scores.Results:Serum adropin levels were found to be high in the PE group. Although the adropin values were high in the case of all comorbidities, the values significantly elevated only in patients with hypertension, acute ischaemic stroke, and previous history of PE. The adropin values were quite different among the Wells score categories, and the mean adropin levels varied significantly between the PE and control groups.Conclusion:In this study, the plasma adropin levels were significantly high in patients with acute PE and exhibited high positive predictivity, sensitivity, and specificity in detecting PE.

Keywords

• adropin
• atherothrombosis
• endothelial function
• pulmonary embolism