Nature Communications (Aug 2016)
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma
- Kouya Shiraishi,
- Yukinori Okada,
- Atsushi Takahashi,
- Yoichiro Kamatani,
- Yukihide Momozawa,
- Kyota Ashikawa,
- Hideo Kunitoh,
- Shingo Matsumoto,
- Atsushi Takano,
- Kimihiro Shimizu,
- Akiteru Goto,
- Koji Tsuta,
- Shun-ichi Watanabe,
- Yuichiro Ohe,
- Yukio Watanabe,
- Yasushi Goto,
- Hiroshi Nokihara,
- Koh Furuta,
- Akihiko Yoshida,
- Koichi Goto,
- Tomoyuki Hishida,
- Masahiro Tsuboi,
- Katsuya Tsuchihara,
- Yohei Miyagi,
- Haruhiko Nakayama,
- Tomoyuki Yokose,
- Kazumi Tanaka,
- Toshiteru Nagashima,
- Yoichi Ohtaki,
- Daichi Maeda,
- Kazuhiro Imai,
- Yoshihiro Minamiya,
- Hiromi Sakamoto,
- Akira Saito,
- Yoko Shimada,
- Kuniko Sunami,
- Motonobu Saito,
- Johji Inazawa,
- Yusuke Nakamura,
- Teruhiko Yoshida,
- Jun Yokota,
- Fumihiko Matsuda,
- Keitaro Matsuo,
- Yataro Daigo,
- Michiaki Kubo,
- Takashi Kohno
Affiliations
- Kouya Shiraishi
- Division of Genome Biology, National Cancer Center Research Institute
- Yukinori Okada
- Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Atsushi Takahashi
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yukihide Momozawa
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
- Kyota Ashikawa
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
- Hideo Kunitoh
- Department of Medical Oncology, Japanese Red Cross Medical Center
- Shingo Matsumoto
- Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Research Institute
- Atsushi Takano
- Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo
- Kimihiro Shimizu
- Department of Integrative Center of General Surgery, Gunma University Hospital
- Akiteru Goto
- Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University
- Koji Tsuta
- Department of Pathology, National Cancer Center Hospital
- Shun-ichi Watanabe
- Division of Thoracic Surgery, National Cancer Centre Hospital
- Yuichiro Ohe
- Department of Thoracic Oncology, National Cancer Center Hospital
- Yukio Watanabe
- Division of Thoracic Surgery, National Cancer Centre Hospital
- Yasushi Goto
- Department of Thoracic Oncology, National Cancer Center Hospital
- Hiroshi Nokihara
- Department of Thoracic Oncology, National Cancer Center Hospital
- Koh Furuta
- Department of Clinical Laboratories, National Cancer Center Hospital
- Akihiko Yoshida
- Department of Pathology, National Cancer Center Hospital
- Koichi Goto
- Department of Thoracic Oncology, National Cancer Center Hospital East
- Tomoyuki Hishida
- Department of Thoracic Surgery, National Cancer Center Hospital East
- Masahiro Tsuboi
- Department of Thoracic Surgery, National Cancer Center Hospital East
- Katsuya Tsuchihara
- Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Research Institute
- Yohei Miyagi
- Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute
- Haruhiko Nakayama
- Department of Thoracic Surgery, Kanagawa Cancer Center
- Tomoyuki Yokose
- Department of Pathology, Kanagawa Cancer Center
- Kazumi Tanaka
- Department of Integrative Center of General Surgery, Gunma University Hospital
- Toshiteru Nagashima
- Department of Integrative Center of General Surgery, Gunma University Hospital
- Yoichi Ohtaki
- Department of Integrative Center of General Surgery, Gunma University Hospital
- Daichi Maeda
- Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University
- Kazuhiro Imai
- Department of Thoracic Surgery, Graduate School of Medicine, Akita University
- Yoshihiro Minamiya
- Department of Thoracic Surgery, Graduate School of Medicine, Akita University
- Hiromi Sakamoto
- Division of Genetics, National Cancer Center Research Institute
- Akira Saito
- StaGen Co., Ltd.
- Yoko Shimada
- Division of Genome Biology, National Cancer Center Research Institute
- Kuniko Sunami
- Division of Genome Biology, National Cancer Center Research Institute
- Motonobu Saito
- Division of Genome Biology, National Cancer Center Research Institute
- Johji Inazawa
- Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University
- Yusuke Nakamura
- Department of Medicine and Department of Surgery, Center for Personalized Therapeutics, The University of Chicago
- Teruhiko Yoshida
- Division of Genetics, National Cancer Center Research Institute
- Jun Yokota
- Genomics and Epigenomics of Cancer Prediction Program, Institute of Predictive and Personalized Medicine of Cancer (IMPPC)
- Fumihiko Matsuda
- Center for Genomic Medicine, Graduate School of Medicine, Kyoto University
- Keitaro Matsuo
- Division of Division of Molecular Medicine, Aichi Cancer Center Research Institute
- Yataro Daigo
- Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo
- Michiaki Kubo
- Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
- Takashi Kohno
- Division of Genome Biology, National Cancer Center Research Institute
- DOI
- https://doi.org/10.1038/ncomms12451
- Journal volume & issue
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Vol. 7,
no. 1
pp. 1 – 7
Abstract
EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer.
