Mechanisms of carcinogenesis prevention by flavonoids

Abstract

The mechanisms of anticancerogenic effects of flavanoids and isocyanates from the plants widely consumed in the midland belt of Russia were reviewed. Data of studies both in vitro and in vivo were analyzed. Special attention was paid to inhibition of targets responsible for carcinogen metabolic activation, carcinogenesis promotion and tumor progression as well as neoangiogenesis. Besides that the antioxidant properties of flavonoids and their effects on cell cycle regulation, apoptosis initiation and cell mobility were considered.

Keywords

• flavonoids
• isocyanates
• carcinogenesis prevention
• nutritional supplements
• toxicity
• antioxidants
• ah-receptor