Polydeoxyribonucleotide: A promising skin anti-aging agent

Aawrish Khan; Guobao Wang; Feng Zhou; Lunli Gong; Jun Zhang; Lili Qi; Haiyan Cui

Chinese Journal of Plastic and Reconstructive Surgery (Dec 2022)

Polydeoxyribonucleotide: A promising skin anti-aging agent

Aawrish Khan,
Guobao Wang,
Feng Zhou,
Lunli Gong,
Jun Zhang,
Lili Qi,
Haiyan Cui

Affiliations

Aawrish Khan: Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China
Guobao Wang: Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China
Feng Zhou: Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China
Lunli Gong: Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China
Jun Zhang: Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China
Lili Qi: Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China
Haiyan Cui: Corresponding author. Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, 389 Xincun Road, Putuo District, Shanghai 200065, China.; Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China

Journal volume & issue: Vol. 4, no. 4
pp. 187 – 193

Abstract

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Polydeoxyribonucleotide (PDRN) consists of DNA fragments with molecular weights ranging from 50 to 1 500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many preclinical and clinical studies have demonstrated the properties of PDRN. These include anti-inflammatory, anti-apoptotic, anti-osteoporotic, anti-melanogenetic, anti-allodynic, anti-osteonecrotic, bone regenerative, tissue damage preventive, anti-ulcerative, and wound healing properties, which are mediated by the activation of the adenosine A2A receptor and salvage pathways. Moreover, PDRN promotes angiogenesis, cellular activity, collagen synthesis, soft tissue regeneration, and skin priming and revitalization and can be used to treat hyperpigmentation. Therefore, this review assessed the potential use of PDRN as an anti-aging agent for the skin.

Published in Chinese Journal of Plastic and Reconstructive Surgery

ISSN: 2096-6911 (Print); 2772-686X (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Medicine: Surgery
Website: https://www.keaipublishing.com/en/journals/chinese-journal-of-plastic-and-reconstructive-surgery/

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Abstract

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