A Mini Review of <i>S</i>-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
Hui Ming,
Kunpeng Zhang,
Shengbo Ge,
Yang Shi,
Chunan Du,
Xuqiang Guo,
Libo Zhang
Affiliations
Hui Ming
State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China
Kunpeng Zhang
State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China
Shengbo Ge
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China
Yang Shi
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China
Chunan Du
Faculty of Chemical Engineering, Shandong Institute of Petroleum and Chemical Technology, Dongying 257000, China
Xuqiang Guo
State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China
Libo Zhang
State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China
As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
