Nature Communications (Jan 2018)

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

  • Masayuki Furuya,
  • Junichi Kikuta,
  • Sayumi Fujimori,
  • Shigeto Seno,
  • Hiroki Maeda,
  • Mai Shirazaki,
  • Maki Uenaka,
  • Hiroki Mizuno,
  • Yoriko Iwamoto,
  • Akito Morimoto,
  • Kunihiko Hashimoto,
  • Takeshi Ito,
  • Yukihiro Isogai,
  • Masafumi Kashii,
  • Takashi Kaito,
  • Shinsuke Ohba,
  • Ung-il Chung,
  • Alexander C. Lichtler,
  • Kazuya Kikuchi,
  • Hideo Matsuda,
  • Hideki Yoshikawa,
  • Masaru Ishii

DOI
https://doi.org/10.1038/s41467-017-02541-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of osteoclasts, and that the interaction is modulated by parathyroid hormone administration.