<i>Ferulago</i> <i>nodosa</i> Subsp. <i>geniculata</i> (Guss.) Troia & Raimondo from Sicily (Italy): Isolation of Essential Oil and Evaluation of Its Bioactivity
Natale Badalamenti,
Vincenzo Ilardi,
Sergio Rosselli,
Maurizio Bruno,
Filippo Maggi,
Mariarosaria Leporini,
Tiziana Falco,
Monica R. Loizzo,
Rosa Tundis
Affiliations
Natale Badalamenti
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, ed. 17, I-90128 Palermo, Italy
Vincenzo Ilardi
Department of Earth and Marine Sciences (DISTeM), University of Palermo, Via Archirafi 26, I-90128 Palermo, Italy
Sergio Rosselli
Department of Agricultural, Food and Forest Sciences (SAAF), University of Palermo, Viale delle Scienze, ed. 4, I-90128 Palermo, Italy
Maurizio Bruno
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, ed. 17, I-90128 Palermo, Italy
Filippo Maggi
School of Pharmacy, University of Camerino, Via Sant’Agostino 1, I-62032 Camerino, Italy
Mariarosaria Leporini
Department of Pharmacy, Health Science and Nutrition, University of Calabria, I-87036 Arcavacata Rende (CS), Italy
Tiziana Falco
Department of Pharmacy, Health Science and Nutrition, University of Calabria, I-87036 Arcavacata Rende (CS), Italy
Monica R. Loizzo
Department of Pharmacy, Health Science and Nutrition, University of Calabria, I-87036 Arcavacata Rende (CS), Italy
Rosa Tundis
Department of Pharmacy, Health Science and Nutrition, University of Calabria, I-87036 Arcavacata Rende (CS), Italy
Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area. The object of the present study is Sicilian F. nodosa subsp. geniculata (Guss.) Troia & Raimondo, classified as an endemic F. nodosa subspecies. Aerial parts of this plant species were subjected to hydrodistillation to obtain an essential oil. A total of 93 compounds were identified with 2,3,6-trimethyl benzaldehyde (19.0%), spathulenol (9.0%), (E)-caryophyllene (5.4%), and caryophyllene oxide (5.4%) as the main components. The biological activities of F. nodosa essential oil were also investigated. This oil showed an interesting antioxidant potential in a 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) test (IC50 of 14.05 μg/mL). Additionally, hypoglycemic and antilipidemic effects were evaluated. Lipase enzyme was inhibited with an IC50 value of 41.99 μg/mL. Obtained data demonstrated that F. nodosa could be considered a promising source of bioactive compounds useful for the treatment and management of obesity.
