Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge

Shuyue Ren; Peirong Lin; Jingrong Wang; Haoying Yu; Tingting Lv; Lan Sun; Guanhua Du

Molecular Therapy: Methods & Clinical Development (Sep 2020)

Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge

Shuyue Ren,
Peirong Lin,
Jingrong Wang,
Haoying Yu,
Tingting Lv,
Lan Sun,
Guanhua Du

Affiliations

Shuyue Ren: Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China
Peirong Lin: Department of Anesthesiology, Beijing AnZhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China
Jingrong Wang: Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China
Haoying Yu: Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China
Tingting Lv: Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China
Lan Sun: Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China; Corresponding author: Lan Sun, Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China.
Guanhua Du: Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China; Corresponding author: Guanhua Du, Chinese Academy of Medical Science and Peking Union Medical College, Institute of Materia Medica, The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, and Beijing Key Laboratory of Drug Targets Identification and Drug Screening, 1 Xian Nong Tan Street, Beijing 100050, China.

Journal volume & issue: Vol. 18
pp. 215 – 229

Abstract

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Circular RNAs (circRNAs) are a new class of noncoding single-stranded RNAs that differ from linear microRNAs (miRNAs), since they form covalently closed loop structures without free 3′ poly(A) tails or 5′ caps. circRNAs are the competitive endogenous RNAs (ceRNAs) by binding to miRNA through miRNA response elements (MREs) (i.e., “miRNA sponge”), thereby reducing the quantity of miRNA available to target mRNA, subsequently promoting mRNA stability or protein expression, which involves the initiation and progress of human diseases. Owing to these features of abundance, stability, conservative property, and tissue and stage specificity, widely distributing in the extracellular space and in various bodily fluids, circRNAs can be considered as potential biomarkers for various diseases. Here, we reviewed the promising circRNAs being disease biomarkers, focused on their regulatory function by acting as miRNA sponges, and described their roles in cancer, cardiovascular or neurodegenerative diseases, osteoarthritis, rheumatoid arthritis, diabetes, and other human aging-related diseases, which provide a new direction for pathogenesis, diagnosis, and treatment of human aging-related diseases.

Published in Molecular Therapy: Methods & Clinical Development

ISSN: 2329-0501 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Biology (General): Genetics; Science: Biology (General): Cytology
Website: http://www.cell.com/molecular-therapy-family/methods/latest-content

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