Nature Communications (Oct 2021)

Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture

  • Qiang Shan,
  • Xiang Li,
  • Xia Chen,
  • Zhouhao Zeng,
  • Shaoqi Zhu,
  • Kexin Gai,
  • Weiqun Peng,
  • Hai-Hui Xue

DOI
https://doi.org/10.1038/s41467-021-26159-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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How CD8+ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8+ T cells.