Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

Chandran Ramakrishna; Maciej Kujawski; Hiutung Chu; Lin Li; Sarkis K. Mazmanian; Edouard M. Cantin

doi:10.1038/s41467-019-09884-6

Nature Communications (May 2019)

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis

Chandran Ramakrishna,
Maciej Kujawski,
Hiutung Chu,
Lin Li,
Sarkis K. Mazmanian,
Edouard M. Cantin

Affiliations

Chandran Ramakrishna: Department of Molecular Immunology, Beckman Research Institute of City of Hope
Maciej Kujawski: Department of Molecular Immunology, Beckman Research Institute of City of Hope
Hiutung Chu: Division of Biology and Biological Sciences, California Institute of Technology
Lin Li: Department of Molecular Immunology, Beckman Research Institute of City of Hope
Sarkis K. Mazmanian: Division of Biology and Biological Sciences, California Institute of Technology
Edouard M. Cantin: Department of Molecular Immunology, Beckman Research Institute of City of Hope

DOI: https://doi.org/10.1038/s41467-019-09884-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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The capsular polysaccharide A (PSA) of Bacteroides fragilis is known to have immunomodulatory capability during sterile inflammatory disorders. Here Ramakrishna and colleagues show that PSA administration in a murine model of herpes simplex encephalitis induces IL-10 producing B and T cell populations that confer protection against lethal challenge and brain pathology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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