Technology in Cancer Research & Treatment (Nov 2020)

Expression and Clinical Significance of MMP-28 in Bladder Cancer

  • Heng Wang MS,
  • Jun-xiu Wu MS,
  • Xin-Peng Chen MS,
  • Qi Zhang MD,
  • Hai-bin Wei MD,
  • Hui-Ju Wang PhD,
  • Xue Yang MS,
  • Da-Hong Zhang MD

DOI
https://doi.org/10.1177/1533033820974017
Journal volume & issue
Vol. 19

Abstract

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Aims: The aim of this study to determine the expression of MMP-28 in bladder urothelial carcinoma and to analyze the correlation between MMP-28 and the clinicopathological characteristics of human bladder carcinoma, and its relationship with patient prognosis. Methods: A total of 491 surgically resected bladder cancer samples and 80 normal tissue adjacent to the tumor were stained by immunohistochemistry. The expression of MMP-28 in these samples was quantitated, and the value of MMP-28 as a marker of bladder cancer and prognosis was assessed. Results: The expression of MMP-28 in urinary bladder carcinoma was higher than in normal bladder mucosa. The high level of MMP-28 was significantly correlated with tumor histology grade, lymphatic metastasis, lymph node infiltration, and distant metastasis (P < 0.05). The upregulation of MMP-28 was also closely related to the risk of cancer progression and the survival of patients. Further analysis documented that high expression of MMP-28 was associated with decreased overall survival in bladder cancer patients. Conclusions: The abnormal expression of MMP-28 may be related to the initiation and development of urothelial carcinoma. The upregulation of MMP-28 can be used as one of the effective indicators to diagnose bladder cancer and predict tumor progression.