The relationship between bone mineral density and hematological parameters in the geriatric age group

Abstract

Introduction: As populations gradually become older, osteoporosis manifests itself asan important public health problem. Studies have shown that inflammation playsa critical role in the pathogenesis of osteoporosis. NLR (neutrophil tolymphocyte ratio) and PLR (platelet to lymphocyte ratio) are simple,non-invasive, and inexpensive markers of inflammation in malignancies andinflammatory diseases. This study aims to compare osteopenic, osteoporotic, andcontrol subjects, who do not have other known diseases or a history ofmedication use, in terms of their NLR and PLR levels and evaluate therelationship between NLR, PLR levels and BMD.Methods: This cross-sectional study included a total of 308 patients aged 65 orabove. Total bone mineral density (BMD) was measured using dual energy X-rayabsorptiometry (DEXA). Complete blood count (CBC), biomarkers of inflammation(C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), glucose/lipidmetabolism, and thyroid function test results were recorded.Results: The osteoporosis group demonstrated higher NLR levels compared to theosteopenic and control groups (respectively 3.58 ± 4.22,2.64 ± 1.99, and 2.36 ± 1.39), and thisrelationship between the groups was found to be statistically significant(p=0.025). Our data revealed higher sedimentation values for the osteoporosisgroup than for the osteopenic and healthy control groups with statisticalsignificance (p=0.011).Conclusions: The fact that individuals with geriatric osteoporosis demonstrateelevated NLR levels and that this elevation is also seen in sedimentationsuggests that inflammation plays an important role in bone remodelling.

Keywords

• kemik mineral dansitesi
• nötrofil/lenfosit oranı
• trombosit/lenfosit oranı
• inflamasyon
• bone mineral density
• neutrophil to lymphocyte ratio
• platelet to lymphocyte ratio
• inflammation