Nature Communications (Nov 2018)
Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
- Ze Rui Wu,
- Lichong Yan,
- Yan Ting Liu,
- Lei Cao,
- Yu Hang Guo,
- Yong Zhang,
- Hong Yao,
- Lin Cai,
- Han Bing Shang,
- Wei Wei Rui,
- Gang Yang,
- Xiao Biao Zhang,
- Hao Tang,
- Yu Wang,
- Jin Yan Huang,
- Yong Xu Wei,
- Wei Guo Zhao,
- Bing Su,
- Zhe Bao Wu
Affiliations
- Ze Rui Wu
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Lichong Yan
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Yan Ting Liu
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Lei Cao
- Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University
- Yu Hang Guo
- Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University
- Yong Zhang
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Hong Yao
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Lin Cai
- Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University
- Han Bing Shang
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Wei Wei Rui
- Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Gang Yang
- Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University
- Xiao Biao Zhang
- Department of Neurosurgery, Zhongshan Hospital, Fudan University
- Hao Tang
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Yu Wang
- Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine
- Jin Yan Huang
- State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Yong Xu Wei
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Wei Guo Zhao
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Bing Su
- Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine
- Zhe Bao Wu
- Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06853-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show that H19 lncRNA is downregulated in pituitary adenomas and H19 is able to impede pituitary tumorigenesis via disruption of 4E-BPB1 and Raptor interaction to inhibit the phosphorylation of 4E-BP1.
