ASSOCIATION OF CERTAIN SINGLE NUCLEOTIDE POLYMORPHISM GENES OF APOPTOSIS SYSTEM WITH A RISK OF DEVELOPMENT OF COLORECTAL CANCER IN RUSSIAN POPULATION

Abstract

Aim. Study the effect of single nucleotide polymorphism genes TP53 (rsl042522, rsl 800371), CDKN2A (rs3731217, rs3088440) and MDM2 (rs2279744) on the risk of development of colorectal cancer (CRC) in population of Perm Region. Materials and methods. Case group consisted of 198 patients with histologically verified CRC, control group - 205 individuals with CRC excluded by results of colonoscopy. DNA genotyping, obtained from leukocytes of venous blood of the studied individuals, was carried out by PCR with electrophoretic detection of results. Results. Significant inter-population differences of frequency of occurrence of alleles rs 1042522, rs3088440, rs2279744 in Russian population compared with East-Asian and European were detected (p

Keywords

• snps
• cdkn2a
• mdm2
• colon cancer
• snps
• apoptosis
• tp53
• cdkn2a
• mdm2