Nature Communications (Mar 2022)
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
- David Stacey,
- Lingyan Chen,
- Paulina J. Stanczyk,
- Joanna M. M. Howson,
- Amy M. Mason,
- Stephen Burgess,
- Stephen MacDonald,
- Jonathan Langdown,
- Harriett McKinney,
- Kate Downes,
- Neda Farahi,
- James E. Peters,
- Saonli Basu,
- James S. Pankow,
- Weihong Tang,
- Nathan Pankratz,
- Maria Sabater-Lleal,
- Paul S. de Vries,
- Nicholas L. Smith,
- CHARGE Hemostasis Working Group,
- Amy D. Gelinas,
- Daniel J. Schneider,
- Nebojsa Janjic,
- Nilesh J. Samani,
- Shu Ye,
- Charlotte Summers,
- Edwin R. Chilvers,
- John Danesh,
- Dirk S. Paul
Affiliations
- David Stacey
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Lingyan Chen
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Paulina J. Stanczyk
- Department of Cardiovascular Sciences, University of Leicester
- Joanna M. M. Howson
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Amy M. Mason
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Stephen Burgess
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Stephen MacDonald
- Specialist Haemostasis Unit, Cambridge University Hospitals NHS Foundation Trust
- Jonathan Langdown
- Specialist Haemostasis Unit, Cambridge University Hospitals NHS Foundation Trust
- Harriett McKinney
- Department of Haematology, University of Cambridge
- Kate Downes
- Department of Haematology, University of Cambridge
- Neda Farahi
- Department of Medicine, University of Cambridge
- James E. Peters
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Saonli Basu
- Division of Biostatistics, School of Public Health, University of Minnesota
- James S. Pankow
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Weihong Tang
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Nathan Pankratz
- Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota
- Maria Sabater-Lleal
- Genomics of Complex Diseases Group, Sant Pau Biomedical Research Institute, IIB-Sant Pau
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences; School of Public Health, The University of Texas Health Science Center at Houston
- Nicholas L. Smith
- Department of Epidemiology, School of Public Health, University of Washington
- CHARGE Hemostasis Working Group
- Amy D. Gelinas
- SomaLogic Inc
- Daniel J. Schneider
- SomaLogic Inc
- Nebojsa Janjic
- SomaLogic Inc
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester
- Shu Ye
- Department of Cardiovascular Sciences, University of Leicester
- Charlotte Summers
- Department of Medicine, University of Cambridge
- Edwin R. Chilvers
- National Heart and Lung Institute, Imperial College London
- John Danesh
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Dirk S. Paul
- British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-022-28729-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Many individual genetic risk loci associate with multiple diseases, but the molecular basis of these loci often remains unclear. Here, the authors provide a framework to reveal the genetic cross-disease associations at the PROCR vascular disease locus.
