Nature Communications (Dec 2022)
Genomics and phenomics of body mass index reveals a complex disease network
- Jie Huang,
- Jennifer E. Huffman,
- Yunfeng Huang,
- Ítalo Do Valle,
- Themistocles L. Assimes,
- Sridharan Raghavan,
- Benjamin F. Voight,
- Chang Liu,
- Albert-László Barabási,
- Rose D. L. Huang,
- Qin Hui,
- Xuan-Mai T. Nguyen,
- Yuk-Lam Ho,
- Luc Djousse,
- Julie A. Lynch,
- Marijana Vujkovic,
- Catherine Tcheandjieu,
- Hua Tang,
- Scott M. Damrauer,
- Peter D. Reaven,
- Donald Miller,
- Lawrence S. Phillips,
- Maggie C. Y. Ng,
- Mariaelisa Graff,
- Christopher A. Haiman,
- Ruth J. F. Loos,
- Kari E. North,
- Loic Yengo,
- George Davey Smith,
- Danish Saleheen,
- J. Michael Gaziano,
- Daniel J. Rader,
- Philip S. Tsao,
- Kelly Cho,
- Kyong-Mi Chang,
- Peter W. F. Wilson,
- VA Million Veteran Program,
- Yan V. Sun,
- Christopher J. O’Donnell
Affiliations
- Jie Huang
- School of Public Health and Emergency Management, Southern University of Science and Technology
- Jennifer E. Huffman
- Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Yunfeng Huang
- Department of Epidemiology, Emory University Rollins School of Public Health
- Ítalo Do Valle
- Network Science Institute and Department of Physics, Northeastern University
- Themistocles L. Assimes
- VA Palo Alto Health Care System
- Sridharan Raghavan
- VA Eastern Colorado Healthcare System
- Benjamin F. Voight
- Corporal Michael J. Crescenz VA Medical Center
- Chang Liu
- Department of Epidemiology, Emory University Rollins School of Public Health
- Albert-László Barabási
- Network Science Institute and Department of Physics, Northeastern University
- Rose D. L. Huang
- Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Qin Hui
- Department of Epidemiology, Emory University Rollins School of Public Health
- Xuan-Mai T. Nguyen
- Carle Illinois College of Medicine
- Yuk-Lam Ho
- Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Luc Djousse
- Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Julie A. Lynch
- VA Salt Lake City Healthcare
- Marijana Vujkovic
- Corporal Michael J. Crescenz VA Medical Center
- Catherine Tcheandjieu
- VA Palo Alto Health Care System
- Hua Tang
- VA Palo Alto Health Care System
- Scott M. Damrauer
- Corporal Michael J. Crescenz VA Medical Center
- Peter D. Reaven
- Phoenix VA Health Care System
- Donald Miller
- Center for Healthcare Organization and Implementation Research, Bedford VA Medical Center
- Lawrence S. Phillips
- Atlanta VA Health Care System
- Maggie C. Y. Ng
- Vanderbilt Genetics Institute and Division of Genetic Medicine, Vanderbilt University Medical Center
- Mariaelisa Graff
- Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina Chapel Hill
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Kari E. North
- Gillings School of Global Public Health, Department of Epidemiology, University of North Carolina Chapel Hill
- Loic Yengo
- Institute for Molecular Bioscience, The University of Queensland
- George Davey Smith
- Population Health Sciences, Bristol Medical School, University of Bristol
- Danish Saleheen
- Center for Non-Communicable Diseases
- J. Michael Gaziano
- Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Daniel J. Rader
- Department of Medicine; Perelman School of Medicine, University of Pennsylvania
- Philip S. Tsao
- VA Palo Alto Health Care System
- Kelly Cho
- Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- Kyong-Mi Chang
- Corporal Michael J. Crescenz VA Medical Center
- Peter W. F. Wilson
- Department of Epidemiology, Emory University Rollins School of Public Health
- VA Million Veteran Program
- Yan V. Sun
- Department of Epidemiology, Emory University Rollins School of Public Health
- Christopher J. O’Donnell
- Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System
- DOI
- https://doi.org/10.1038/s41467-022-35553-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Elevated body mass index is heritable and associated with many health conditions that impact morbidity and mortality. Here, the authors identify greater than 900 genetic loci for body mass index (BMI) and find over 300 diagnoses associated with increasing BMI.
